诊断研究组

(一)本组简介

本组主要负责人为葛胜祥教授,现有教师1名、高级工程师2名、在读博士生11名、在读研究生14名、技术员2名,是一支富有创新性和凝聚力的研究小组。本的主要研究方向为体外诊断技术平台与诊断产品研发,旨在提高重大传染病和肿瘤、心血管疾病等重大慢性疾病的体外诊断水平。此外,在传染病流行病学、基因工程疫苗等方面也开展了大量的工作。研制的体外诊断产品已获国家药品监督管理局医疗器械注册证书120余项,并获得保护WHO PQFDA等海外注册证书30余项;研究的轮状病毒基因工程疫苗已成功授权给法国赛诺菲·巴斯德。

(二)导师

葛胜祥,博士,教授,博士生导师,Emailsxge@xmu.edu.cn

李廷栋,博士,高级工程师,Emaillitingdong@xmu.edu.cn

张师音,博士,高级工程师,Emailzhangshiyin@xmu.edu.cn

(三)正在开展的项目

  • 体外诊断技术:基于微流控的分子POCT平台、超敏免疫检测技术、miRNA高敏检测方法、外泌体直接捕获检测技术

  • 体外诊断检测靶标:活动性结核检测靶标、新型鼻咽癌筛查靶标、新冠抗体检测新靶标、胰腺癌检测新靶标

  • 基因工程疫苗:轮状病毒基因工程疫苗及其保护机制研究

  • 其他:大分子胞内递送系统

(四)近5年来发表的部分文章

[1] ZHAO J, YUAN Q, WANG H, et al. Antibody responses to SARS-CoV-2 in patients of novel coronavirus disease 2019 [J]. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2020,

[2] LOU B, LI T D, ZHENG S F, et al. Serology characteristics of SARS-CoV-2 infection after exposure and post-symptom onset [J]. Eur Respir J, 2020, 56(2):

[3] LIU Y, LI X, LIU W, et al. IL-6 release of Rv0183 antigen-stimulated whole blood is a potential biomarker for active tuberculosis patients [J]. Journal of Infection, 2017, S0163445317303766.

[4] ZHUO Z, WANG J, CHEN W, et al. A Rapid On-Site Assay for the Detection of Influenza A by Capillary Convective PCR [J]. Mol Diagn Ther, 2018, 22(2): 225-34.

[5] LI T, GUO X, JI M, et al. Establishment and validation of a two-step screening scheme for improved performance of serological screening of nasopharyngeal carcinoma [J]. Cancer Med, 2018, 7(4): 1458-67.

[6] LI Y, XUE M, YU L, et al. Expression and characterization of a novel truncated rotavirus VP4 for the development of a recombinant rotavirus vaccine [J]. Vaccine, 2018, 36(16): 2086-92.

[7] GUO X, LI T, LI F, et al. Intermittent abortive reactivation of Epstein-Barr virus during the progression of nasopharyngeal cancer as indicated by elevated antibody levels [J]. Oral Oncol, 2019, 93(85-90.

[8] LIU W, LIANG H, WANG S, et al. Transcriptional response of USP18 predicts treatment outcomes of interferon-alpha in HBeAg-positive chronic hepatitis B patientsefere [J]. J Viral Hepat, 2019, 26(9): 1050-8.

[9] ZHANG J, SU X, XU J, et al. A point of care platform based on microfluidic chip for nucleic acid extraction in less than 1 minute [J]. Biomicrofluidics, 2019, 13(3): 034102.

[10] CHEN M, HE S, YAN Q, et al. Severe hand, foot and mouth disease associated with Coxsackievirus A10 infections in Xiamen, China in 2015 [J]. Journal of clinical virology, 2017, 93(20-4.

(五)招生要求

生物学各专业、预防医学、基础医学或临床医学各专业,其他专业学生诺有兴趣可邮件联系。


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国家传染病诊断试剂与疫苗工程技术研究中心(厦门大学)  地址:中国福建省厦门市翔安区翔安南路厦门大学翔安校区
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