郑子峥

郑子峥,厦门大学,公共卫生学院,副教授


病毒-宿主相互作用研究组组长国家传染病诊断试剂与疫苗工程技术研究中心(NIDVD)分子疫苗学与分子诊断学国家重点实验室(SKLVD)



教育经历:

  1. 1. 2004/9–2012/6, 厦门大学, 生物化学与分子生物学, 博士

  2. 2. 2000/9–2004/6, 厦门大学, 生物学, 学士


科研与学术工作经历:

  1. 2016/8-至今,厦门大学,公共卫生学院,副教授

  2. 2012/7-2016/7,厦门大学,公共卫生学院,助理教授

  3. 2008-至今,厦门大学NIDVD,病毒-宿主相互作用研究组组长


现阶段主要研究兴趣:

  1. 病毒、疫苗诱导的宿主B细胞(抗体)免疫应答研究(戊型肝炎病毒、乙型肝炎病毒、流感病毒、呼吸道合胞病毒)

  2. 病毒受体、感染机制及免疫逃逸机制研究(戊型肝炎病毒、呼吸道合胞病毒)

  3. 戊型肝炎临床新特征及肝外感染症状研究

  4. 呼吸道合胞病毒(致儿童肺炎)预防及治疗性疫苗、药物研发

  5. 肿瘤组织浸润性B细胞研究


部分代表性论文:

  1. Chang Liu, Wei Cai, Xin Yin, Zimin Tang, Guiping Wen, Charuta Ambardekar, Xinlei Li, Dong Ying, Zongdi Feng*, Zizheng Zheng*, Ningshao Xia, An Optimized High-Throughput Neutralization Assay for Hepatitis E Virus (HEV) Involving Detection of Secreted Porf2, Viruses, 2019, 11(1) (Co-Corresponding author)

  2. Xue Liu#, Chao Liu#, Zizheng Zheng#, Siyuan Chen, Xin Pang, Xinchu Xiang, Jixian Tang, En Ren, Yuanzhi Chen, Min You, Xiaoyong Wang, Xiaoyuan Chen, Wenxin Luo,* Gang Liu,* and Ningshao Xia*. Vesicular Antibodies: A Bioactive Multifunctional Combination Platform for Targeted Therapeutic Delivery and Cancer Immunotherapy. Advanced Materials, 2019, (Accepted, Co-First author)

  3. Si-Ling Wang, Birendra Prasad Gupta, Wen-Fang Ji, Zi-Min Tang, Gui-Ping Wen, Anurag Adhikari, Dong Ying, Xu Zhang, Chang Liu, Zi-Zheng Zheng*, Ning-Shao Xia. Application of Hepatitis E Virus-Related Markers on Samples from a Developing Country. Clin. Lab. 2019;65:235-241 (Corresponding author)

  4. Xin Yin, Dong Ying, Sébastien Lhomme, Zimin Tang, Christopher M. Walker, Ningshao Xia, Zizheng Zheng*, Zongdi Feng*, Origin, antigenicity, and function of a secreted form of ORF2 in hepatitis E virus infection, Proceedings of the National Academy of Sciences of USA, 2018, 115(18): 4773-4778 (Co-Corresponding author)

  5. Guiping Wen, Changrong Chen, Xiuyu Song, Zimin Tang, Wenfang Ji, Siling Wang, Ke Zhang, Jun Zhang, Shanhai Ou*, Zizheng Zheng*, Ningshao Xia, Long-term HEV carriers without antibody seroconversion among eligible immunocompetent blood donors, Emerging Microbes & Infecttions, 2018, 7(1): 125 (Co-Corresponding author)

  6. Min Zhao#, Zi-Zheng Zheng#, Man Chen, Kayvon Modjarrad, Wei Zhang, Lu-Ting Zhan, Jian-Li Cao, Yong-Peng Sun, Jason S. McLellan, Barney S. Graham*, Ning-Shao Xia*, Discovery of prefusion respiratory syncytial virus F-specific monoclonal antibody that provides greater in vivo protection than the murine precursor of Palivizumab, Journal of Virology, 2017, 91(15): 1-17 (Co-First author)

  7. Tian, Daiyin#; Battles, Michael B.#; Moin, Syed M.; Chen, Man; Modjarrad, Kayvon; Kumar, Azad; Kanekiyo, Masaru; Graepel, Kevin W.; Taher, Noor M.; Hotard, Anne L.; Moore, Martin L.; Zhao, Min; Zheng, Zi-Zheng; Xia, Ning-Shao*; McLellan, Jason S.*; Graham, Barney S*. Structural basis of respiratory syncytial virus subtype-dependent neutralization by an antibodytargeting the fusion glycoprotein, Nature Communications, 2017.11.30, 8: 1~7

  8. Wen, Gui-Ping#; Tang, Zi-Min#; Wang, Si-Ling; Ji, Wen-Fang; Cai, Wei; Zhang, Xu; Huang, Shou-Jie; Wu, Ting; Zhang, Jun; Zheng, Zi-Zheng*; Xia, Ning-Shao*, Classification of human and zoonotic group hepatitis E virus (HEV) using antigen detection, Applied Microbiology and Biotechnology, 2017.12, 101(23-24): 8585~8594(Co-Corresponding author)

  9. Cai, Wei#; Tang, Zi-Min#; Wen, Gui-Ping; Wang, Si-Ling; Ji, Wen-Fang; Yang, Min; Ying, Dong; Zheng, Zi-Zheng*; Xia, Ning-Shao*. A high-throughput neutralizing assay for antibodies and sera against hepatitis E virus, Scientific Reports, 2016.4.28, 6: 1~8(Co-Corresponding author)

  10. Tang, Zi-Min; Wang, Si-Ling; Ying, Dong; Wen, Gui-Ping; Cai, Wei; Zhang, Ke; Ji, Wen-Fang; Yang, Ming; Zheng, Zi-Zheng*; Xia, Ning-Shao*. The Bama miniature swine is susceptible to experimental HEV infection, Scientific Reports, 2016.8.18, 6: 1~6(Co-Corresponding author)

  11. Wen, Gui-Ping#; Tang, Zi-Min#; Yang, Fan; Zhang, Ke; Ji, Wen-Fang; Cai, Wei; Huang, Shou-Jie; Wu, Ting; Zhang, Jun; Zheng, Zi-Zheng*; Xia, Ning-Shao*. A valuable antigen detection method for diagnosis of acute hepatitis e. Journal of Clinical Microbiology, 2015.3.01, 53(3): 782~788(Co-Corresponding author)

  12. Min Zhao#, Xiao-Jing Li#, Zi-Min Tang, Fan Yang, Si-Ling Wang, Wei Cai, Ke Zhang, Ning-Shao Xia*, Zi-Zheng Zheng*, A comprehensive study of neutralizing antigenic sites on the hepatitis E virus (HEV) capsid by constructing, clustering and characterizing a tool box, Journal of Biological Chemistry, 2015, 290(32): 19910-19922 (Co-Corresponding author)

  13. Tang, Zi-Min#; Tang, Ming#; Zhao, Min; Wen, Gui-Ping; Yang, Fan; Cai, Wei; Wang, Si-Ling; Zheng, Zi-Zheng*; Xia, Ning-Shao*. A novel linear neutralizing epitope of hepatitis E virus. Vaccine, 2015.7.9, 33(30): 3504~3511 (Co-Corresponding author)

  14. McLellan, Jason S ; Chen, Man; Leung, Sherman; Graepel, Kevin W; Du, Xiulian; Yang, Yongping; Zhou, Tongqing; Baxa, Ulrich; Yasuda, Etsuko;Beaumont, Tim; Kumar, Azad; Modjarrad, Kayvon; Zheng, Zizheng; Zhao, Min; Xia, Ningshao; Kwong, Peter D ; Graham, Barney SStructure of RSV fusion glycoprotein trimer bound to a prefusion-specific neutralizing antibody. Science, 2013.5.31, 340(6136): 1113~1117

  15. McLellan, Jason S; Chen, Man; Joyce, M Gordon; Sastry, Mallika; Stewart-Jones, Guillaume B E; Yang, Yongping; Zhang, Baoshan; Chen, Lei; Srivatsan, Sanjay; Zheng, Anqi; Zhou, Tongqing; Graepel, Kevin W; Kumar, Azad; Moin, Syed; Boyington, Jeffrey C; Chuang, Gwo-Yu; Soto, Cinque; Baxa, Ulrich; Bakker, Arjen Q; Spits, Hergen; Beaumont, Tim; Zheng, Zizheng; Xia, Ningshao; Ko, Sung-Youl; Todd, John-Paul; Rao, Srinivas; Graham, Barney S ; Kwong, Peter D , Structure-based design of a fusion glycoprotein vaccine forrespiratory syncytial virus. Science, 2013.11.1, 342(6158): 592~598


授权发明专利

  1. 郑子峥,贾森·麦克莱伦,陈曼,赵敏,黄粱敏,巴尼·格雷厄姆,夏宁邵,RSV融合蛋白的表位以及识别其的抗体, 2019.01.17,澳大利亚,2014231357

  2. 郑子峥,贾森·麦克莱伦,陈曼,赵敏,黄粱敏,巴尼·格雷厄姆,夏宁邵,RSV融合蛋白的表位以及识别其的抗体, 2018.01.02,美国,US9856313B2

  3. 郑子峥,唐自闽,赵敏,李晓静,温桂平,李婧娴,张军,夏宁邵,特异结合戊型肝炎病毒34型的抗体及其用途, 2017.08.25,中国,ZL201310069913.4


主持或参加科研项目(部分):

1. 国家自然科学基金面上项目,81871247,戊型肝炎病毒分泌型衣壳蛋白的结构与功能探究,2019/01-2022/12,主持

2. 国家科技重大专项传染病重大专项(2018ZX10101001-002),试剂的预认证和海外分子流行病学研究,2018/01-2020/12,主持

3. 国家自然科学基金青年科学基金项目,8170061359,中和抗体对不同类型HEV的保护机制,2018/01-2020/12, 在研,参加、骨干成员

4. 福建省自然科学基金资助项目,2016J05201,戊型肝炎病毒基因型间宿主差异的分子机制研究,2016/04-2019/03已结题,主持

5. 国家自然科学基金青年科学基金项目,81401668,抗呼吸道合胞病毒高中和活性抗体的保护机制研究,2015/01-2017/12,已结题,主持

6. 国家自然科学基金国际(地区)合作与交流项目,81361120408,单克隆抗体中和呼吸道合胞病毒的结构基础,2014/01-2016/12,已结题,参加、骨干成员

7. 国家自然科学基金国际(地区)合作与交流项目,81161120419,中和呼吸道合胞病毒感染的分子结构基础,2012/01-2012/12,已结题,参加、骨干成员



获得学术奖励

  1. 求是奖杰出科技成就集体奖, 2015

  2. 创新人才推进计划重点领域创新团队-疫苗与体外诊断创新团队, 2013


上一条:赵勤俭 下一条:郑清炳

国家传染病诊断试剂与疫苗工程技术研究中心(厦门大学)  地址:中国福建省厦门市翔安区翔安南路厦门大学翔安校区
电话:0592-2183111 传真:0592-2181258  邮编:361102
ICP备案号:D200327