郑清炳

郑清炳

工程师,厦门大学公共卫生学院      

电话:13779936654

电子邮件:qbzheng@xmu.edu.cn

工作地址:厦门大学翔安校区椭圆楼118室


教育经历

· 2003.9-2007.6  学士,生物技术专业,生命科学学院,厦门大学

· 2007.8-2013.9  博士,细胞生物学专业,生命科学学院,厦门大学

工作经历

· 2013.9-至今  厦门大学公共卫生学院工程师,冷冻电镜平台负责人

· 2016.10-2016.12  加州大学洛杉矶分校(UCLA),访问学者

研究方向

· 高分辨冷冻电镜三维重构

· 结构疫苗学

代表性论文

[1] Zheng, Q.*, Zhu, R.*, Xu, L.*, He, M.*, Yan, X.*, Liu, D., Yin, Z., Wu, Y., Li, Y., Yang, L., Hou, W., Li, S., Li, Z., Chen, Z., Li, Z., Yu, H., Gu, Y., Zhang, J., Baker, T. S., Zhou, Z. H., Graham, B. S., Cheng, T., Li, S., and Xia, N. (2019) Atomic structures of enterovirus D68 in complex with two monoclonal antibodies define distinct mechanisms of viral neutralization, Nature microbiology 4, 124-133. (* co-first authors)

[2] Zhu, R.*, Xu, L.*, Zheng, Q.*, Cui, Y.*, Li, S.*, He, M., Yin, Z., Liu, D., Li, S., Li, Z., Chen, Z., Yu, H., Que, Y., Liu, C., Kong, Z., Zhang, J., Baker, T. S., Yan, X., Hong Zhou, Z., Cheng, T., and Xia, N. (2018) Discovery and structural characterization of a therapeutic antibody against coxsackievirus A10, Science advances 4, eaat7459. (* co-first authors)

[3] Zhang, T. Y., Guo, X. R., Wu, Y. T., Kang, X. Z., Zheng, Q. B., Qi, R. Y., Chen, B. B., Lan, Y., Wei, M., Wang, S. J., Xiong, H. L., Cao, J. L., Zhang, B. H., Qiao, X. Y., Huang, X. F., Wang, Y. B., Fang, M. J., Zhang, Y. L., Cheng, T., Chen, Y. X., Zhao, Q. J., Li, S. W., Ge, S. X., Chen, P. J., Zhang, J., Yuan, Q., and Xia, N. S. (2019) A unique B cell epitope-based particulate vaccine shows effective suppression of hepatitis B surface antigen in mice, Gut pii: gutjnl-2018-317725.

[4] Li, T., Zhang, Z., Zhang, Z., Qiao, J., Rong, R., Zhang, Y., Yao, Q., Li, Z., Shen, H., Huang, F., Xue, W., Gao, S., Li, S., Zheng, Q., Yu, H., Zhang, J., Gu, Y., Li, S., and Xia, N. (2019) Characterization of native-like HIV-1 gp140 glycoprotein expressed in insect cells, Vaccine 37, 1418-1427.

[5] Chen, T., Wang, K., Chi, X., Zhou, L., Li, J., Liu, L., Zheng, Q., Wang, Y., Yu, H., Gu, Y., Zhang, J., Li, S., and Xia, N. (2019) Construction of a bacterial surface display system based on outer membrane protein F, Microbial cell factories 18, 70.

[6] Wang, K., Zhou, L., Zhang, X., Song, C., Chen, T., Li, J., Zheng, M., Wang, Y., Zheng, Q., Zheng, Z., Yu, H., Wu, T., Gu, Y., Zhang, J., Zhao, Q., Li, S., and Xia, N. (2019) Hepatitis E vaccine candidate harboring a non-particulate immunogen of E2 fused with CRM197 fragment A, Antiviral Res 164, 154-161.

[7] Zhang, J., Gui, X., Zheng, Q., Chen, Y., Ge, S., Zhang, J., and Xia, N. (2019) An HRP-labeled lateral flow immunoassay for rapid simultaneous detection and differentiation of influenza A and B viruses, Journal of medical virology 91, 503-507.

[8] Shen, C., Zhang, M., Chen, Y., Zhang, L., Wang, G., Chen, J., Chen, S., Li, Z., Wei, F., Chen, J., Yang, K., Guo, S., Wang, Y., Zheng, Q., Yu, H., Luo, W., Zhang, J., Chen, H., Chen, Y., and Xia, N. (2019) An IgM antibody targeting the receptor binding site of influenza B blocks viral infection with great breadth and potency, Theranostics 9, 210-231.

[9] Zhang, Z., He, M., Bai, S., Zhang, F., Jiang, J., Zheng, Q., Gao, S., Yan, X., Li, S., Gu, Y., and Xia, N. (2018) T = 4 Icosahedral HIV-1 Capsid As an Immunogenic Vector for HIV-1 V3 Loop Epitope Display, Viruses 10.

[10] Wei, M., Wang, D., Li, Z., Song, S., Kong, X., Mo, X., Yang, Y., He, M., Li, Z., Huang, B., Lin, Z., Pan, H., Zheng, Q., Yu, H., Gu, Y., Zhang, J., Li, S., and Xia, N. (2018) N-terminal truncations on L1 proteins of human papillomaviruses promote their soluble expression in Escherichia coli and self-assembly in vitro, Emerging microbes & infections 7, 160.

[11] Lin, Q., Li, T., Chen, Y., Lau, S. Y., Wei, M., Zhang, Y., Zhang, Z., Yao, Q., Li, J., Li, Z., Wang, D., Zheng, Q., Yu, H., Gu, Y., Zhang, J., Chen, H., Li, S., and Xia, N. (2018) Structural Basis for the Broad, Antibody-Mediated Neutralization of H5N1 Influenza Virus, Journal of virology 92.

[12] Li, Z., Song, S., He, M., Wang, D., Shi, J., Liu, X., Li, Y., Chi, X., Wei, S., Yang, Y., Wang, Z., Li, J., Qian, H., Yu, H., Zheng, Q., Yan, X., Zhao, Q., Zhang, J., Gu, Y., Li, S., and Xia, N. (2018) Rational design of a triple-type human papillomavirus vaccine by compromising viral-type specificity, Nature communications 9, 5360.

[13] Xu, L.*, Zheng, Q.*, Li, S.*, He, M., Wu, Y., Li, Y., Zhu, R., Yu, H., Hong, Q., Jiang, J., Li, Z., Li, S., Zhao, H., Yang, L., Hou, W., Wang, W., Ye, X., Zhang, J., Baker, T. S., Cheng, T., Zhou, Z. H., Yan, X., and Xia, N. (2017) Atomic structures of Coxsackievirus A6 and its complex with a neutralizing antibody, Nature communications 8, 505. (* co-first authors)

[14] Xin, L., Yu, H., Hong, Q., Bi, X., Zhang, X., Zhang, Z., Kong, Z., Zheng, Q., Gu, Y., Zhao, Q., Zhang, J., Li, S., and Xia, N. (2017) Identification of Strategic Residues at the Interface of Antigen-Antibody Interactions by In Silico Mutagenesis, Interdisciplinary sciences, computational life sciences.

[15] Shen, C., Chen, J., Li, R., Zhang, M., Wang, G., Stegalkina, S., Zhang, L., Chen, J., Cao, J., Bi, X., Anderson, S. F., Alefantis, T., Zhang, M., Cai, X., Yang, K., Zheng, Q., Fang, M., Yu, H., Luo, W., Zheng, Z., Yuan, Q., Zhang, J., Wai-Kuo Shih, J., Kleanthous, H., Chen, H., Chen, Y., and Xia, N. (2017) A multimechanistic antibody targeting the receptor binding site potently cross-protects against influenza B viruses, Science translational medicine 9.

[16] Li, Z., Wang, D., Gu, Y., Song, S., He, M., Shi, J., Liu, X., Wei, S., Li, J., Yu, H., Zheng, Q., Yan, X., Baker, T. S., Zhang, J., McLellan, J. S., Li, S., and Xia, N. (2017) Crystal Structures of Two Immune Complexes Identify Determinants for Viral Infectivity and Type-Specific Neutralization of Human Papillomavirus, mBio 8.

[17] Zhang, X., Wang, K., Lin, Q., Zheng, M., Li, Q., Li, T., Hong, Q., Zheng, Q., Yu, H., Gu, Y., Li, S., and Xia, N. (2016) A shared N-terminal hydrophobic tail for the formation of nanoparticulates, Nanomedicine 11, 2289-2303.

[18] Yang, L., Liu, Y., Li, S., Zhao, H., Lin, Q., Yu, H., Huang, X., Zheng, Q., Cheng, T., and Xia, N. (2016) A novel inactivated enterovirus 71 vaccine can elicit cross-protective immunity against coxsackievirus A16 in mice, Vaccine 34, 5938-5945.

[19] Li, Z., Yan, X., Yu, H., Wang, D., Song, S., Li, Y., He, M., Hong, Q., Zheng, Q., Zhao, Q., Gu, Y., Zhang, J., Janssen, M. E., Cardone, G., Olson, N. H., Baker, T. S., Li, S., and Xia, N. (2016) The C-Terminal Arm of the Human Papillomavirus Major Capsid Protein Is Immunogenic and Involved in Virus-Host Interaction, Structure 24, 874-885.

[20] Zhang, P., Chen, Y., Zeng, Y., Shen, C., Li, R., Guo, Z., Li, S., Zheng, Q., Chu, C., Wang, Z., Zheng, Z., Tian, R., Ge, S., Zhang, X., Xia, N. S., Liu, G., and Chen, X. (2015) Virus-mimetic nanovesicles as a versatile antigen-delivery system, Proc Natl Acad Sci 112, E6129-6138.

[21] Huang, C. H., Yuan, Q., Chen, P. J., Zhang, Y. L., Chen, C. R., Zheng, Q. B., Yeh, S. H., Yu, H., Xue, Y., Chen, Y. X., Liu, P. G., Ge, S. X., Zhang, J., and Xia, N. S. (2012) Influence of mutations in hepatitis B virus surface protein on viral antigenicity and phenotype in occult HBV strains from blood donors, Journal of hepatology 57, 720-729.

[22] Zheng, Q.*, Xia, L.*, Wu, W. L., Zheng, Z., Huo, Y., Wu, J., Liu, Y., Yu, H., Chen, Y., Lau, S. Y., Chen, H., Luo, W., and Xia, N. (2011) Properties and therapeutic efficacy of broadly reactive chimeric and humanized H5-specific monoclonal antibodies against H5N1 influenza viruses, Antimicrobial agents and chemotherapy 55, 1349-1357. (* co-first authors)

[23] Chen, Y.*, Zheng, Q.*, Yang, K., Zeng, F., Lau, S. Y., Wu, W. L., Huang, S., Zhang, J., Chen, H., and Xia, N. (2011) Serological survey of antibodies to influenza A viruses in a group of people without a history of influenza vaccination, Clinical microbiology and infection 17, 1347-1349. (* co-first authors)



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