赵勤俭

赵勤俭

博士,教授,博士生导师,公共卫生学院副院长

国家特聘专家

通信地址:厦门大学翔安校区公共卫生学院

邮编:361102

电话:0592-2180936

电子邮箱:qinjian_zhao@xmu.edu.cn


教育经历:

(1) 1981.9–1986.7, 北京医科大学, 药物化学, 学士

(2) 1986.9–1989.7, 北京医科大学, 药物化学, 硕士

(3) 1989.9–1993.11, 美国天主教大学, 生物有机化学, 博士

工作经历:

(1) 2015.10-至今, 厦门大学, 公共卫生学院, 特聘教授,公共卫生学院副院长

(2) 2011.6-2015.10, 厦门大学, 公共卫生学院, 特聘教授

(3) 1997.7-2011.6, 美国默克公司研发部, 生物化学研究者、研究员、高级研究员、杰出高级研究员/科学主任

(4) 1993.11-1997.6, 约翰•霍普金斯大学医学院,药理与分子科学系及生物化学系,博士后

研究领域:

(1)生物大分子药物及疫苗制剂的质量分析

重组类病毒颗粒(virus-like particles, VLPs)

表位鉴定(Epitope identification)

体外相对效力分析(in vitro relative potency, IVRP)

(2)新型疫苗佐剂研究

佐剂制备、理化性质鉴定

安全性、有效性评估

免疫调节机制

(3)The Strategic Advisory Group of Expert, World Health Organization.    

主持课题:

1. 国家自然科学基金重点项目,31730029,多聚化抗原诱导高效体液免疫应答的机制研究,2018/01-2022/12,250万,在研,参与(核心骨干成员)

2. 国家自然科学基金面上项目,31670939,植物源多糖及寡糖引发平衡的Th1/Th2类免疫反应机制研究,2017/01-2020/12,60万,在研,主持

3. 国家自然科学基金面上项目,81471934,人乳头瘤病毒样颗粒不同中和表位的特性与结构基础研究,2015/01-2018/12,72万,已结题,主持

4. 国家自然科学基金面上项目,81273327,人乳头瘤病毒样颗粒表位的鉴定和中和机制研究,2013/01-2013/12,16万,已结题,主持

5. “十二五”863 重大项目,2012AA02A408,疫苗研发关键技术及产品研发,2012/01-2015/12,1600万元,已结题,主持

获得荣誉:

1.求是杰出科技成就集体奖,香港求是科技基金会,国际学术奖,2015年9月(夏宁邵,李少伟,张军,吴婷,黄守杰,李益民,葛胜祥,顾颖,郑子峥,袁权,潘晖榕,吴文翰,赵勤俭,史维国,罗文新,陈毅歆,程通,俞海)

2.“比尔·梅琳达盖茨基金会旅行奖”,MIT-UCL 疫苗生物工艺发展及商业化研讨会,2015年6月

3.作为疫苗与诊断试剂创新团队核心人员,入选 “创新人才推进计划重点领域创新团队”,授予单位:中国科学技术部,2013年4月

4.荣获“工业生物技术奖”,授予单位:美国化学学会生物化学技术部,2006年9月

近五年代表性论文(第一作者或通讯作者):

1.Siyi Chen, Xiaofen Huang, Yike Li, Xin Wang, Huirong Pan, Zhijie Lin, Qingbing Zheng, Shaowei Li, Jun Zhang, Ningshao Xia*, Qinjian Zhao*. Altered antigenicity and immunogenicity of human papillomavirus virus-like particles in the presence of thimerosal. European Journal of Pharmaceutics and Biopharmaceutics. 2019, 141:221-231.

2.Kaihang Wang, Lizhi Zhou, Xiao Zhang, Cuiling Song, Tingting Chen, Jiajia Li, Minghua Zheng, Yingbin Wang, Qingbing Zheng, Zizheng Zheng, Hai Yu, Ting Wu, Ying Gu, Jun Zhang, Qinjian Zhao*, Shaowei Li*, Ningshao Xia. Hepatitis E vaccine candidate harboring a non-particulate immunogen of E2 fused with CRM197 fragment A. Antiviral Research. 2019, 164:154-161.

3.Xin Wang, Min Li, Zhijie Lin, Huirong Pan, Zimin Tang, Zizheng Zheng, Shaowei Li, Jun Zhang, Ningshao Xia*, Qinjian Zhao*. Multifaceted characterization of recombinant protein-based vaccines: An immunochemical toolbox for epitope-specific analyses of the hepatitis E vaccine. Vaccine. 2018, 36(50):7650-7658.

4.Cai Zhang, Xiaofen Huang, Siyi Chen, Yike Li, Yufang Li, Xin Wang, Jixian Tang, Lin Xia, Zhijie Lin, Wenxin Luo, Tingdong Li, Shaowei Li, Jun Zhang, Ningshao Xia*, Qinjian Zhao*. Epitope clustering analysis for vaccine-induced human antibodies in relationship to a panel of murine monoclonal antibodies against HPV16 viral capsid. Vaccine. 2018, 36(45):6761-6771.

5.Zhigang Zhang, Jun Zhang, Ningshao Xia, Qinjian Zhao*. Expanded strain coverage for a highly successful public health tool: Prophylactic 9-valent human papillomavirus vaccine. Human Vaccines & Immunotherapeutics. 2017, 13(10):2280-2291.

6.Xin Wang, Zhiqiang An, Wenxin Luo, Ningshao Xia, Qinjian Zhao*. Molecular and functional analysis of monoclonal antibodies in support of biologics development. Protein & Cell. 2017. 9(1):74–85.

7.Yahua Lin, Xin Wang, Xiaofen Huang, Jun Zhang, Ningshao Xia, Qinjian Zhao*. Calcium phosphate nanoparticles as a new generation vaccine adjuvant. Expert Review of Vaccines. 2017, 16(9):895-906.

8.Xiaofen Huang, Xin Wang, Jun Zhang, Ningshao Xia, Qinjian Zhao*. Escherichia coli-derived virus-like particles in vaccine development. npj Vaccines. 2017: 3.

9.Zhang X, Wei M, Sun G, Wang X, Li M, Lin Z, Li Z, Li Y, Fang M, Zhang J, Li S, Xia N*, Zhao Q*. Vaccine. Real-time stability of a hepatitis E vaccine (Hecolin®) demonstrated with potency assays and multifaceted physicochemical methods. Vaccine, 2016, 34(48):5871-5877.

10.Qinjian Zhao*, Ningshao Xia*. The 2016 Lasker-DeBakey Clinical Medical Research Award: Innovative hepatitis C virus (HCV) replicons leading to drug development for hepatitis C cure. Sci China Life Sci. 2016, DOI: 10.1007/s11427-016-0313-9

11.Lu Cao, Xin Wang, Mujin Fang, Ningshao Xia, Qinjian Zhao*. Detection of subtle differences in analogous viral capsid proteins by allowing unrestricted specific interaction in solution competition ELISA. Journal of Virological Methods, 2016, 236: 1-4.

12.Min Li, Xin Wang, Lu Cao, Zhijie Lin, Minxi Wei, Mujin Fang, Shaowei Li, Jun Zhang, Ningshao Xia*, Qinjian Zhao*. Quantitative and epitope-specific antigenicity analysis of the human papillomavirus 6 capsid protein in aqueous solution or when adsorbed on particulate adjuvants. Vaccine, 2016, 34(37): 4422-4428.

13.Qingshan Lin, Kunyu Yang, Fangping He, Jie Jiang,  Tingting Li, Zhenqin Chen, Rui Li, Yixin Chen, Shaowei Li*, Qinjian Zhao*, Ningshao Xia. Production of Influenza Virus HA1 Harboring Native-Like Epitopes by Pichia pastoris. Applied Biochemistry and Biotechnology, 2016, 179(7): 1275–1289.

14.Lin Xia#, Yangfei Xian#, Daning Wang, Yuanzhi Chen, Xiaofen Huang, Xingjian Bi, Hai Yu, Zheng Fu, Xinlin Liu, Shaowei Li, Zhiqiang An, Wenxin Luo*, Qinjian Zhao*, Ningshao Xia. A human monoclonal antibody against HPV16 recognizes an immunodominant and neutralizing epitope partially overlapping with that of H16.V5. Scientific Report, 2016, 6: 19042.

15.Xiao Zhang, Shaowei Li, Yorgo Modis, Zhihai Li, Jun Zhang, Ningshao Xia*, Qinjian Zhao*. Functional assessment and structural basis of antibody binding to human papillomavirus capsid. Review in Medical Virology, 2016, 26:115-128.

16.Xin Wang, Min Li, Shaowei Li, Ting Wu, Jun Zhang, Ningshao Xia*, Qinjian Zhao*. Prophylaxis against Hepatitis E: at risk populations and human vaccines. Expert review of vaccines, 2016, 15(7): 815-827.

17.Yue Zhang, Min Li, Fan Yang, Yufang Li, Zizheng Zheng, Xiao Zhang, Qingshan Lin, Ying Wang, Shaowei Li, Ningshao Xia, Jun Zhang* & Qinjian Zhao*. Comparable quality attributes of hepatitis E vaccine antigen with and without adjuvant adsorption-dissolution treatment, Human Vaccines & Immunotherapeutics, 2015, 11:5, 1129-1139.

18.Xiao Zhang, Lu Xin, Shaowei Li, Mujin Fang, Jun Zhang, Ningshao Xia* & Qinjian Zhao*. Lessons learned from successful human vaccines: Delineating key epitopes by dissecting the capsid proteins, Human Vaccines &Immunotherapeutics, 2015, 11:5, 1277-1292.


下一条:郑子峥

国家传染病诊断试剂与疫苗工程技术研究中心(厦门大学)  地址:中国福建省厦门市翔安区翔安南路厦门大学翔安校区
电话:0592-2183111 传真:0592-2181258  邮编:361102
ICP备案号:D200327