张 军

Jun Zhang 张军 (教授,博士生导师,副院长)

Prof. Zhang received his bachelor degree and master degree from Shanghai Medical University in 1994 and 1997 respectively. 2007-Present Professor, Deputy Director of National Institute of Diagnostics and Vaccine Development in Infectious Disease, Xiamen University。

1994 年上海医科大学预防医学学士、1997年上海医科大学流行病学专业硕士。现任厦门大学公共卫生学院副院长,教授,博士生导师,国家传染病诊断试剂与疫苗工程技术研 究中心副主任, 2005年列入教育部新世纪优秀人才培养计划。获国家科技进步二等奖(第2完成人)、国家技术发明二等奖(第4完成人)、教育部提名国家科技进步二等奖 (第1完成人)等科技奖励。


近年来主持或参加科研项目(课题)情况:


1、重组人乳头瘤病毒(HPV16/18型双价疫苗的随机对照试验(RCT

2、重组人乳头瘤病毒(HPV6/11/16/18/31/33/45/52/58型九价疫苗的随机对照试验(RCT

3、重组人乳头瘤病毒(HPV6/11型双价疫苗的随机对照试验(RCT

4、冻干水痘减毒活疫苗(VZV-7D)的随机对照试验(RCT)、

5、巨细胞病毒(CMV)感染危险因素的队列研究、

6、人乳头瘤病毒感染及相关疾病的流行病学调查、

7、福建省人乳头瘤病毒疫苗卫生经济学评价及应用策略研究(福建省卫生教育联合攻关计划)

8、慢性肝炎及肝硬化患者接种重组戊型肝炎疫苗(大肠埃希菌)益可宁的开放性临床试验

9、福建省科技重大专项, HEV/HPV 多价联合疫苗研究与产品开发

10、国家自然科学基金面上项目,巨细胞病毒抗体阳性孕妇母婴传播高危群体的鉴别新方法研究

11、国家自然科学基金中美生物医学合作试点项目中和呼吸道合胞病毒感染的分子结构基础

12863计划重大项目课题,开放式全自动管式化学发光免疫检测系统的研制

13、国家自然科学基金面上项目,肠道病毒71型高通量快速中和实验方法的研究

14、福建省自然科学基金杰出青年基金项目,中国隐匿性乙型肝炎病毒感染的分子病毒学研究

15、国家科技重大专项“传染病防治”课题,重组(大肠杆菌)类病毒颗粒疫苗研制关键技术平台



代表性研究成果



(1) Zhang J ; Zhang XF ; Huang SJ; Wu T; Hu YM; Wang ZZ; Wang H; Jiang HM; Wang YJ; Yan Q; Guo M; Liu XH; Li JX; Yang CL; Tang Q; Jiang RJ; Pan HR; Li YM; Shih JW; Ng MH; Zhu FC ; Xia NS ,Long-Term Efficacy of a Hepatitis E Vaccine , New England Journal of Medicine, 2015.3.5, 372(10): 914~922 (期刊论文)

(2) Zhu FC ; Zhang J ; Zhang XF; Zhou C; Wang ZZ; Huang SJ; Wang H; Yang CL; Jiang HM; Cai JP; Wang YJ; Ai X; Hu YM; Tang Q; Yao X; Yan Q; Xian YL; Wu T; Li YM; Miao J; Ng MH; Shih JW; Xia NS ,Efficacy and safety of a recombinant hepatitis E vaccine in healthy adults: a large-scale, randomised, double-blind placebo-controlled, phase 3 trial , Lancet, 2010.9.11, 376(9744):895~902 (期刊论文)

(3) Huang Y; Guo XY; Song QQ ; Wang H; Yu H; Zhang YR; Qiao EY; Xue WW; Li XG; Zhuang SJ; Wei FX; Li TD; Ge SX; Wu T; Xia NS; Zhang J ,Cytomegalovirus shedding in healthy seropositive female college students: a six-month longitudinal study. , J Infect Dis (期刊论文)

(4) Li TD; Li JJ; Huang X; Wang H; Guo XY; Ge SX ; Zhang J ,Baseline antibody level may help predict the risk of active human cytomegalovirus infection in a HCMV seropositive population , European Journal of Clinical Microbiology & Infectious Diseases, 2017.5, 36(5): 863~868 (期刊论文)

(5) Yuan Q ; Song LW; Liu CJ; Li Z; Liu PG; Huang CH; Yan Y; Ge SX; Wang YB; Peng CY; Zhang J; Kao JH; Chen DS; Chen PJ; Xia NS ,Quantitative hepatitis B core antibody level may help predict treatment response in chronic hepatitis B patients , Gut, 2013.1, 62(1): 182~184 (期刊论文)

(6) Huang CH ; Yuan Q ; Chen PJ; Zhang YL; Chen CR; Zheng QB; Yeh SH; Yu H; Xue Y; Chen YX; Liu PG; Ge SX; Zhang J ; Xia NS ,Influence of mutations in hepatitis B virus surface protein on viral antigenicity and phenotype in occult HBV strains from blood donors , Journal of Hepatology, 2012.10, 57(4):720~729 (期刊论文)

(7) Zhang J ; Zhang XF  ; Zhou C; Wang ZZ; Huang SJ; Yao X; Liang ZL; Wu T; Li JX; Yan Q; Yang CL; Jiang HM; Huang HJ; Xian YL; Shih JW; Ng MH; Li YM; Wang JZ ; Zhu FC ; Xia NS ,Protection against hepatitis E virus infection by naturally acquired and vaccine-induced immunity , Clinical Microbiology and Infection, 2014.6, 20(6): O397~O405 (期刊论文)

(8) Su YY ; Huang SJ ; Guo M; Zhao J; Yu H; He WG; Jiang HM; Wang YJ; Zhang XF; Cai JP; Yang CL; Wang ZZ; Zhu FC; Wu T ; Zhang J  ; Xia NS, Persistence of antibodies acquired by natural hepatitis E virus infection and effects of vaccination , Clinical Microbiology and Infection, 2017.5, 23(5):336.e1~336.e4 (期刊论文)

(9) Chen S ; Zhou Z  ; Wei FX; Huang SJ; Tan Z; Fang Y; Zhu FC; Wu T  ;Zhang J ; Xia NS,Modeling the long-term antibody response of a hepatitis E vaccine , Vaccine, 2015.8.7, 33(33): 4124~4129 (期刊论文)

(10) Wu T ; Hu YM ; Li J  ; Chu K; Huang SJ; Zhao H; Wang ZZ; Yang CL; Jiang HM; Wang YJ; Lin ZJ; Pan HR; Sheng W; Wei FX; Li SW; Wang Y; Zhu FC; Li CG; Zhang J ; Xia NS,Immunogenicity and safety of an E. coli-produced bivalent human papillomavirus (type 16 and 18) vaccine: A randomized controlled phase 2 clinical trial , Vaccine, 2015.7.31, 33(32): 3940~3946 (期刊论文)


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国家传染病诊断试剂与疫苗工程技术研究中心(厦门大学)  地址:中国福建省厦门市翔安区翔安南路厦门大学翔安校区
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