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程通

程通,CHENG TongPh.D.

副教授,Associate Professor            

电话:+86-592-2184113

E-mail:tcheng@xmu.edu.cn

1999年,厦门大学生物学专业,学士学位

2006年,厦门大学动物学专业,博士学位

研究领域(Research Area

主要开展病毒分子生物学、分子疫苗学、人源化动物模型研究。负责“国家传染病诊断试剂与疫苗工程技术研究中心”、“分子疫苗学与分子诊断学国家重点实验室”病毒疫苗与感染模型研究组的研究工作。目前研究方向包括人手足口病相关肠道病毒中和表位与广谱疫苗研究,水痘-带状疱疹病毒致病机制与新型疫苗研究,新型溶瘤病毒和人源化动物模型研究。

 

 

近五年发表论文(* 通讯作者):

[1]       Wang W, Wang X, Yang L, Fu W, Pan D, Liu J, Ye J, Zhao Q, Zhu H, Cheng T*, Xia N. Modulation of host CD59 expression by varicella-zoster virus in human xenografts in vivo. Virology. 2016, 491:96-105.

[2]       Zhu R, Liu J, Chen C, Ye X, Xu L, Wang W, Zhao Q, Zhu H, Cheng T*, Xia N. A highly conserved epitope-vaccine candidate against varicella-zoster virus induces neutralizing antibodies in mice. Vaccine. 2016. 34:1589-96.

[3]       Liu J, Ye X, Jia J, Zhu R, Wang L, Chen C, Yang L, Wang Y, Wang W, Ye J, Li Y, Zhu H, Zhao Q, Cheng T*, Xia N*. Serological Evaluation of Immunity to the Varicella-Zoster Virus Based on a Novel Competitive Enzyme-Linked Immunosorbent Assay. Scientific Reports. 2016, 6:20577.

[4]       Ye X, Yang L, Jia J, Han J, Li S, Liu Y, Xu L, Zhao H, Chen Y, Li Y, Cheng T*, Xia N. Development of sandwich ELISAs that can distinguish different types of coxsackievirus A16 viral particles. Appl Microbiol Biotechnol. 2016, 100(6):2809-15

[5]       Yang L, Li S, Liu Y, Hou W, Lin Q, Zhao H, Xu L, He D, Ye X, Zhu H, Cheng T*, Xia N. Construction and characterization of an infectious clone of coxsackievirus A6 that showed high virulence in neonatal mice. Virus Res. 2015, 210:165-168.

[6]       Xu L, He D, Yang L, Li Z, Ye X, Yu H, Zhao H, Li S, Yuan L, Qian H, Que Y, Kuo Shih JW, Zhu H, Li Y, Cheng T*, Xia N*. A Broadly Cross-protective Vaccine Presenting the Neighboring Epitopes within the VP1 GH Loop and VP2 EF Loop of Enterovirus 71. Scientific Reports. 2015, 5:12973.

[7]       LiuJ, Zhu R, Ye X, Yang L, Wang Y, Huang Y, Wu J, Wang W, Ye J, Li Y, Zhao Q, ZhuH, Cheng T*, Xia N. Amonoclonal antibody-based VZV Glycoprotein E Quantitative Assay and ItsApplication on Antigen Quantitation in VZV Vaccine. Appl Microbiol Biotechnol,2015, 99(11):4845-4853

[8]       HouW, Yang L, Li S, Yu H, Xu L, He D, Chen M, He S, Ye X, Que Y, Shih JW, Cheng T*, Xia N*. Constructionand characterization of an infectious cDNA clone of Echovirus 25.Virus Res. 2015, 205:41-44

[9]       HouW, Yang L, He D, Zheng J, Xu L, Liu J, Liu Y, Zhao H, Ye X, Cheng T*, Xia N. Development ofa coxsackievirus A16 neutralization test based on the enzyme-linked immunospotassay. J Virol Methods. 2015, 215-216:56-60

[10]    Xu L, He D, Li Z, Zheng J, Yang L, Yu M, YuH, Chen Y, Que Y, Shih JW, Liu G, Zhang J, Zhao Q, ChengT*, Xia N. Protection againstlethal Enterovirus 71 challenge in mice by a recombinant vaccine candidatecontaining a broadly cross-neutralizing epitope within the VP2 EF loop. Theranostics.2014, 4(5):498-513. (cover paper)

[11]    Yang L, He D, Tang M, Li Z, Liu C, Xu L,Chen Y, Du H, Zhao Q, Zhang J, Cheng T*, Xia N.Development of an enzyme-linked immunosorbent spot assay to measureserum-neutralizing antibodies against coxsackievirus B3. Clin Vaccine Immunol. 2014,21(3):312-20.

[12]    Li Z, Xu L, He D, Yang L, Liu C, Chen Y,Shih JW, Zhang J, Zhao Q, Cheng T*,Xia N*. In Vivo Time-Related Evaluation of a Therapeutic NeutralizationMonoclonal Antibody against Lethal Enterovirus 71 Infection in a Mouse Model. PLoS One. 2014, 9(10):e109391.

[13]    ChenL, Liu J, Wang W, Ye J, Wen L, Zhao Q, Zhu H,Cheng T*, Xia N. Development ofa Varicella-zoster virus neutralization assay using a glycoprotein K antibodyenzyme-linked immunosorbent spot assay. J Virol Methods, 2014, 200C:10-14.

[14]    Wang W, Cheng T*, Ma K, Xia D,Wang Y, Liu J, Du H, Shih JW, Zhang J, Zhao Q, Xia N. Development of a novelbaculovirus titration method using the Enzyme-linked immunosorbent spot(ELISPOT) assay. JVirol Methods. 2013, 188(1-2):114-20.

[15]    Zhang T1,Cheng T1, Wei L,Cai Y, Yeo AE, Han J, Yuan YA, Zhang J, Xia N. Efficient inhibition of HIV-1replication by an artificial polycistronic miRNA construct. Virol J. 2012, 9(1):118. co-1st

[16]    Spiess K, Jeppesen MG, Malmgaard-Clausen M,Krzywkowski K, Dulal K, Cheng T,Hjortø GM, Larsen O, Burg JS, Jarvis MA, Garcia KC, Zhu H, Kledal TN,Rosenkilde MM. Rationally designed chemokine-based toxin targeting the viral Gprotein-coupled receptor US28 potently inhibits cytomegalovirus infection invivo. Proc Natl Acad Sci USA. 2015 Jun 15. pii: 201509392.

[17]    Chen Y, Li C, He D, Cheng T, Ge S, Shih JW, Zhao Q, Chen PJ, Zhang J, Xia N. Antigenic analysis of divergent genotypes human Enterovirus 71 viruses by a panel of neutralizing monoclonal antibodies: Current genotyping of EV71 does not reflect their antigenicity. Vaccine. 2013, 31(2):425-30.

[18]    Selariu A, Cheng T, Tang Q, Silver B, YangL, Liu C, Ye X, Markus A, Goldstein RS, Cruz Cosme RS, Lin Y, Wen L, Qian H,Han J, Dulal K, Huang Y, Li Y, Xia N, Zhu H. ORF7 of Varicella Zoster Virus isa Neurotropic Factor.JVirol. 2012 , 86(16):8614-24.

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