天气预报   今天: 厦门 阵雨 16-19℃ 风力2级 无持续风向 降水概率0%
  中文网站  |  English

首页 > 中心简介 > 研究团队

陈毅歆

陈毅歆,博士,副教授

CHEN YixinPh.D.Associate Prof.                              

国家传染病诊断试剂与疫苗工程技术研究中心单抗组 组长

E-mail: yxchen2008@xmu.edu.cn

 

2008年厦门大学博士毕业,2009年至今任职厦门大学生命科学学院助理教授、副教授,2011年至今兼职厦门大学公共卫生学院。

 

研究领域(Research Area)

针对人类病毒性传染病的病原体开展分子病毒学与免疫学研究,主要涉及流感病毒、肠道病毒和Epstein-Barr病毒等病原体。重点研究病原体靶标蛋白的抗原性变异规律、表位特征及生物学功能等,为研制病原体的诊断试剂、治疗性抗体药物和疫苗提供支持,在广谱免疫策略和广谱治疗性抗体筛选方面有独到经验。

Our group is dedicated to study the molecular virology and immunology of human pathogens. Our primary studying subjects are influenza virus, enterovirus, and Epstein-Barr virus and our aims are to reveal the changing antigenicity of target viral proteins; their key epitopes and their biological functions. Our final goals are to develop diagnostic kit, therapeutic antibody, and vaccine against specific viruses.  We have maintained a leading position in exploring strategies to elicit broad reactive antibodies. 

 

授权发明专利 (Patents)

(1)    陈毅歆,罗文新,张军,夏宁邵,陈鸿霖,管轶。特异性结合H5亚型禽流感病毒血凝素蛋白的单克隆抗体或其结合活性片段及其用途。中国发明专利号:ZL 200810110869.6,中国授权日:2013年5月1日。

(2)    Yixin Chen,Wenxin Luo,Jun Zhang,Ningshao Xia,Yi Guan,Honglin Chen. Monoclonal antibodies binding to avian influenza virus subtype H5 haemagglutinin and uses thereof,美国发明专利号:US8603467B2,美国授权日:2013年12月10日。

(3)    Yixin Chen,Wenxin Luo,Jun Zhang,Ningshao Xia,Yi Guan,Honglin Chen. Monoclonal antibodies binding to avian influenza virus subtype H5 haemagglutinin and uses thereof,欧洲发明专利号:EP2174957A1,欧洲授权日:2016年3月16日。

(4)    陈毅歆,罗文新,张军,夏宁邵,管轶,陈鸿霖。H5亚型禽流感病毒血凝素蛋白的单克隆抗体或其结合片段及其用途。中国发明专利号:ZL201310131000.0,中国授权日:2015年1月21日。

(5)    罗文新,陈毅歆,郑振华,李国强, 陈鸿霖, 张军,夏宁邵。H5亚型禽流感病毒血凝素蛋白的人源化抗体及其用途。中国发明专利号:ZL200910179075.X,中国授权日:2015年1月7日。

(6)    罗文新,陈毅歆,宋慧娟, 陈瑛炜,陈鸿霖, 张军,夏宁邵。H5亚型禽流感病毒保守中和表位模拟肽及其用途。中国发明专利号:ZL200910225192.5,中国授权日:2015年1月14日。

(7)    夏宁邵,张军,葛胜祥,陈毅歆,罗文新。一种H5亚型禽流感病毒血凝素蛋白的单克隆抗体,其制备方法及其用途。中国发明专利号:ZL 200510007308.X,中国授权日:2009年4月1日。

(8)    罗文新,陈瑛炜,王明桥,陈毅歆,张军,夏宁邵。H5亚型禽流感病毒中和表位模拟肽及其用途。中国发明专利号:ZL 200810133705.5,中国授权日:2013年7月3日。

(9)    葛胜祥,徐飞海,翁祖星,程通,何德磊,陈毅歆,陈自敏,夏宁邵。肠道病毒71型的中和表位多肽及其用途,中国发明专利申请号:ZL201110357994.9,中国授权日:2015年4月8日。

 

代表性论文 (Selected Publications) # Co-first author,* Corresponding author

(1)    Shen C#, Chen J#, Li R#, Zhang M#, Wang G#, Stegalkina S, Zhang L, Chen J, Cao J, Bi X, Anderson SF, Alefantis T, Zhang M, Cai X, Yang K, Zheng Q, Fang M, Yu H, Luo W, Zheng Z, Yuan Q, Zhang J, Wai-Kuo Shih J, Kleanthous H, Chen H, Chen Y*, Xia N*. A multimechanistic antibody targeting the receptor binding site potently cross-protects against influenza B viruses. Science Translational Medicine, 2017, 9, eaam5752.

(Science News from 厦门大学: http://news.xmu.edu.cn/c4/8a/c1550a312458/page.htm)

(Science News from 知识分子: https://mp.weixin.qq.com/s/H6OYORNhItj7wzijrTIb6g

(Reprint 全文 pdf: http://stm.sciencemag.org/cgi/rapidpdf/9/412/eaam5752?ijkey=LrbTEN8frYx3o&keytype=ref&siteid=scitransmed)

(Full Text 全文: http://stm.sciencemag.org/cgi/content/full/9/412/eaam5752?ijkey=LrbTEN8frYx3o&keytype=ref&siteid=scitransmed)

(2)    Chen J#, Yang K#, Zhang M*, Shen C, Chen J, Wang G, Huang S, Zhang M, Xiong H, Chen H, Chen Y*, Xia N. Rapid identification of imported influenza viruses at Xiamen International Airport via an active surveillance program. Clinical Microbiology and Infection, 2017 Jun 3. pii: S1198-743X(17)30288-4.

(3)    Chen Y, Chan KH, Hong C, Kang Y, Ge S, Chen H, Wong EY, Joseph S, Patteril NG, Wernery U, Xia N, Lau SK, Woo PC*. A highly specific rapid antigen detection assay for on-site diagnosis of MERS. Journal of Infection 2016 Jul;73(1):82-4.

(4)    Zhang P#, Chen Y#, Zeng Y#, Shen C, Li R, Guo Z, Li S, Zheng Q, Chu C, Wang Z, Zheng Z, Tian R, Ge S, Zhang X, Xia NS, Liu G*, Chen X*.Virus-mimetic nanovesicles as a versatile antigen-delivery system. Proc Natl Acad Sci USA 2015,112(45):E6129-E6138.

(5)    Chen Y, Chan, KH, Kang Y, Chen H, Luk HK, Poon RW, Chan JF, Yuen KY, Xia N, Lau SK and Woo PC. A sensitive and specific antigen detection assay for Middle East respiratory syndrome coronavirus. Emerging Microbes & Infections, 2015,4, e26.  (Science News: http://news.xmu.edu.cn/80/44/c1550a98372/page.htm)

(6)    Gui X#, Li R#, Zhang X, Shen C, Yu H, Guo X, Kang Y, Chen J, Chen H, Chen Y*, Xia N*. An important amino acid in nucleoprotein contributes to influenza A virus replication by interacting with polymerase PB2. Virology, 2014,464-465:11-20.

(7)    Gui X, Ge P, Wang X, Yang K, Yu H, Zhao Q, Chen Y*, Xia N*. Identification of a highly conserved and surface exposed B-cell epitope on the nucleoprotein of influenza A virus. Journal of Medical Virology, 2014,86:995-1002.

(8)    Chen Y#, Li C#, He D, Cheng T, Ge S, Shih JW, Zhao Q, Chen P-J, Zhang J, Xia N. Antigenic analysis of divergent genotypes human Enterovirus 71 viruses by a panel of neutralizing monoclonal antibodies: Current genotyping of EV71 does not reflect their antigenicity. Vaccine, 2013,31:425-30.

(9)    Wu WL, Lau SY, Chen Y, Wang G, Mok BW, Wen X, Wang P, Song W, Lin T, Chan KH, Yuen KY, Chen H. The 2008-2009 H1N1 influenza virus exhibits reduced susceptibility to antibody inhibition: Implications for the prevalence of oseltamivir resistant variant viruses. Antiviral Research, 2012,93:144-153.

(10) Chen Y#, Zheng Q#, Yang K, Zen F, Lau S-Y, Wu WL, Huang S, Zhang J, Chen H, Xia N. Serological survey of antibodies to influenza A viruses on a group of people without a history of influenza vaccination. Clinical Microbiology and Infection, 2011,17:1347-1349.

(11) Zheng Q, Xia L, Wu WL, Zheng Z, Huo Y, Wu J, Liu Y, Yu H, Chen Y, Lau SY, Chen H, Luo W, Xia N. Properties and therapeutic efficacy of broadly reactive chimeric and humanized H5-specific monoclonal antibodies against H5N1 influenza viruses. Antimicrobial Agents and Chemotherapy, 2011,55:1349-1357.

(12) Chen Y, Xu F, Gui X, Yang K, Wu X, Zheng Q, Ge S, Yuan Q, Yeo AET, Zhang J, Guan Y, Chen H, Xia N. A rapid test for the detection of influenza A virus including pandemic influenza A/H1N1 2009. Journal of Virological Methods, 2009,167:100-102.

(13) Chen Y#, Qin K# , Wu WL, Li G, Zhang J, Du H, Ng MH, Shih JWK, Peiris JSM, Guan Y, Chen H, and Xia N. Broad Cross-Protection against H5N1 Avian Influenza Virus Infection by Means of Monoclonal Antibodies that Map to Conserved Viral Epitopes. Journal of Infectious Diseases, 2009,199:49-58.

(14) WL Wu#, Chen Y#, Wang P, Song W, Lau SY, Rayner JM, Smith GJD, Webster RG, Peiris JSM, Lin T, Xia N, Guan Y and Chen H. Antigenic profile of avian H5N1 viruses in Asia from 2002 to 2007. Journal of Virology, 2008,82:1798-1807.

(15) Chen Y, F Xu, X Fan, H Luo, S Ge, Q Zheng, N Xia, H Chen, Y Guan, and J Zhang. Evaluation of a rapid test for detection of H5N1 avian influenza virus. Journal of Virological Methods, 2008,154:213-215.

厦门大学备案号:D200327 版权所有© 厦门大学