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史维国

史维国 教授,博导

1970 年获Vanderbilt University理学博士,曾任美国国立卫生研究院(NIH)Warren Grant Magnuson临床中心输血医学部传染性疾病处输血传播病毒实验室实验室研究分部主任,Warren Grant Magnuson临床中心实验动物委员会主席,美国乔治城大学医学院微生物学系副教授,美国FDA药品与生物制品处官员,FDA杂交瘤委员会成员。 Science、PNAS、J Immuno、Blood、Hepatology等多个学术刊物审稿人。2005年受聘为厦门大学全职特聘教授。一直热心于为众多青年学者提供深造、训练 的机会,其中许多已成为该病毒领域内的活跃科学家。

电话:(0592)2182000
传真:(0592)2181258
电子信箱:jwshih@xmu.edu.cn

研究兴趣:
病毒性肝炎的血清学和分子诊断方法的发展和评估,肝炎病毒疫苗的研发和临床研究设计,新病毒的鉴定等工作。

 

申请美国专利:
US Patent # 5532134: Mycoplasma diagnostic assay
US Patent # 6455249: Method of amplifying DNA and RNA mismatch cleavage products
US Patent # 6492120: Nucleic acid hybridization assay utilizing tricyclic target and signal amplification

近年发表论文:
  (1) Zhang P, Yu MY, Venable R, Alter HJ, Shih JW. Neutralization epitope responsible for the hepatitis B virus subtype-specific protection in chimpanzees. Proc Natl Acad Sci U S A. 2006, 103(24):9214-9219
  (2) Sugauchi F, Wang RY, Qiu Q, Jin B, Alter HJ, Shih JW. Vigorous hepatitis C virus-specific CD4+ and CD8+ T cell responses induced by protein immunization in the presence of Montanide ISA720 plus synthetic oligodeoxynucleotides containing immunostimulatory cytosine-guanine dinucleotide motifs. J Infect Dis. 2006, 193(4):563-572
(3) Umemura T, Wang RY, Schechterly C, Shih JW, Kiyosawa K, Alter HJ. Quantitative analysis of anti-hepatitis C virus antibody-secreting B cells in patients with chronic hepatitis C. Hepatology. 2006, 43(1):91-99.
(4) Jiao X, Wang RY, Feng Z, Hu G, Alter HJ, W -K Shih J. DNA immunization encoding the secreted nonstructural protein 3 (NS3) of hepatitis C virus and enhancing the Th1 type immune response. J Viral Hepat. 2004, 11(1):18-26
  (5) Jiao X, Wang RY, Qiu Q, Alter HJ, Shih JW. Enhanced HCV NS3 specific Th1 immune response induced by co-delivery of protein antigen and CpG with cationic liposomes. J Gen Virol. 2004,85(Pt 6):1545-1553
  (6) Tanaka Y, Pfeiffer R, Yeo AE, Mizokami M, Edlin BR, Castle P, O'Brien TR, Alter HJ, Shih JW. PCR-probe capture hybridization assay and statistical modeling for SEN virus prevalence estimation. J Med Virol. 2004, 73(1):123-130
  (7) Jiao X, Wang RY, Feng Z, Alter HJ, Shih JW. Modulation of cellular immune response against hepatitis C virus nonstructural protein 3 by cationic liposome encapsulated DNA immunization. Hepatology. 2003, 37(2):452-460
  (8) Umemura T, Tanaka Y, Kiyosawa K, Alter HJ, Shih JW. Observation of positive selection within hypervariable regions of a newly identified DNA virus (SEN virus). FEBS Lett. 2002, 510(3):171-174
  (9) Tanaka Y, Primi D, Wang RY, Umemura T, Yeo AE, Mizokami M, Alter HJ, Shih JW. Genomic and molecular evolutionary analysis of a newly identified infectious agent (SEN Virus) and its relationship to the TT Virus family. J Infect Dis. 2001,183(3):359-367
  (10) Shibata M, Wang RY, Yoshiba M, Shih JW, Alter HJ, Mitamura K. The presence of a newly identified infectious agent (SEN Virus) in patients with liver diseases and in blood donors in Japan. J Infect Dis. 2001,184(4):400-404.

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